Large Scale Plants
2 Large Scale Plants: P3, P8, Hydrogenation Plant
P3
- Typical input batch size: 125kg -> 500Kg
- Exposure Control Level: Band 4*
Equipment:
Reactors x 6
Seed Tanks x 2
Cone Mill
Tanks x 8
Drum Charging Unit
Wet Mill
Centrifuge
Laminar Air Flow Booth
Filter Dryers x 2
Pan Dryer
Conical Dryer
P8
- Typical input batch size: 125 Kg -> 410 Kg
- Exposure Control Level: Band 3*
Equipment:
Reactors x 6
Conical Dryer
Tanks x 14
Drum Charging Unit
Centrifuge x 2
Laminar Air Flow Booth
Hydrogenation
- Typical input batch size: 125kg
- Exposure Control Level: Band 4*
Equipment:
Reactors
Seed Tanks
Drum Charging Unit
Laminar Air Flow Booth
Buss loop Hydrogenator
Small Scale Plants
4 Small Scale Plants: P9, P7, P4, P4A
P9
- Typical input batch size: 27kg -> 40Kg
- Cryogenic cooling capability (jacket temperatures down to -80 ºC
- Exposure Control Level: Band 4*
Equipment:
Reactors x 7
Bell Dryers
Drum Charging Unit
Gloveboxes x 2
Centrifuge
Filter Dryers
P7
- Typical input batch size: 30kg -> 180Kg
- Cryogenic cooling capability (jacket temperatures down to -80 ºC
- Exposure Control Level: Band 4*
Equipment:
Reactors x 4
Filter Dryers
Tanks x 3
Drum Charging Unit
Centrifuge x 1
Glovebox x 2
P4
- Typical input batch size: 12-46kg
- Cryogenic cooling capability (jacket temperatures down to -80 ºC
- Exposure Control Level: Band 5*
Equipment:
Reactors x7
Tanks
Drum Charging Unit
Filter Dryers x 2
Gloveboxes x 2
Wetmill
P4A – High Potent Capability
- Typical input batch size: 0.5kg -> 1.5kg
- Exposure Control Level: Band 5*
Equipment:
Reactors x3
Tanks x3
Gloveboxes x 2
Filter Dryers x 1
Swords Campus Band System *
- This Band System is used at the Swords Campus. APIs will be assigned a specific EG (Exposure Guideline) e.g Apixaban is 0.003 mg/m³) therefore band 4
- Intermediates are not assigned an EG, so will instead be placed into a a band & generally controlled to midpoint of band
- The band relates to potency, with band 5 Special Case being the most potent material
- The more potent the material, the more containment required to control the exposure. The engineering in P4/P4A are capable of containing band 5/5 special care
| Band | CRange MG/M³ |
|---|---|
| 1 | 1.0 |
| 2 | 0.1<1.0 |
| 3 | 0.01<0.1 |
| 4 | 0.001<0.01 |
| 5 | 0.001<0.0001 |
| 5 special case | <0.0001 |
Utilities
Chillers
Plants P4, P7, P4A:
- Energy efficient, environmentally friendly bespoke chillers -30c degrees on duty/standby mode
Plants P3, P8:
- Glycol System to -15c degrees on duty/standby mode
- Glycol System +4c degrees on duty/standby mode
- Syltherm System to -30 back up on duty/standby mode
Plant P9:
- Syltherm System -30c degrees on duty/standby mode
Water Purification
Plant P4, P4A, P7:
- High-quality purified water system x 2
Plant P4, P4A, P7:
- High-quality purified water system
- Hydrogenation Plant
- High-quality purified water system
Water Cooling
- 2 x Cooling water reservoirs cooled by 5 cell induced draft counter flow evaporative open cooling towers.
Water Waste
- State of the art waste water treatment plant.
Steam Plant
- Clayton Steam generation plant operating in duty assist mode with back-up steam generation system available.
Thermal Oxidiser
- Fume Abatement System operating at 1,1000°C.
Nitrogen Oxidiser
- Nitrogen generation units using Liquid Nitrogen x 2
- Compressed nitrogen PSA plant x 1
Solvent Recovery Plant
- 12 bulk fresh solvent underground bunded storage tanks
- 10 over ground recovered solvent tanks
Air Compressors
- 3 x compressors supplying compressed air operating in the duty assist standby mode
- Separate breathing air compression system
Generators
- Back-up generator for key functions
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