SK biotek Ireland2020-10-19T14:55:48+00:00

Large Scale Plants

2 Large Scale Plants: P3, P8, Hydrogenation Plant

P3

  • Typical input batch size: 125kg -> 500Kg
  • Exposure Control Level: Band 4*

Equipment:

Reactors x 6

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Seed Tanks x 2

Cone Mill

Tanks x 8

Drum Charging Unit

Wet Mill

Centrifuge

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Laminar Air Flow Booth

Filter Dryers x 2

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Pan Dryer

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Conical Dryer

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P8

  • Typical input batch size: 125 Kg -> 410 Kg
  • Exposure Control Level: Band 3*

Equipment:

Reactors x 6

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Conical Dryer

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Tanks x 14

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Drum Charging Unit

Centrifuge x 2

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Laminar Air Flow Booth

Hydrogenation

  • Typical input batch size: 125kg
  • Exposure Control Level: Band 4*

Equipment:

Reactors

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Seed Tanks

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Drum Charging Unit

Laminar Air Flow Booth

Buss loop Hydrogenator

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Small Scale Plants

4 Small Scale Plants: P9, P7, P4, P4A

P9

  • Typical input batch size: 27kg -> 40Kg
  • Cryogenic cooling capability (jacket temperatures down to -80 ºC
  • Exposure Control Level: Band 4*

Equipment:

Reactors x 7

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Bell Dryers

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Drum Charging Unit

Gloveboxes x 2

Centrifuge

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Filter Dryers

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P7

  • Typical input batch size: 30kg -> 180Kg
  • Cryogenic cooling capability (jacket temperatures down to -80 ºC
  • Exposure Control Level: Band 4*

Equipment:

Reactors x 4

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Filter Dryers

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Tanks x 3

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Drum Charging Unit

Centrifuge x 1

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Glovebox x 2

P4

  • Typical input batch size: 12-46kg
  • Cryogenic cooling capability (jacket temperatures down to -80 ºC
  • Exposure Control Level: Band 5*

Equipment:

Reactors x7

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Tanks

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Drum Charging Unit

Filter Dryers x 2

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Gloveboxes x 2

Wetmill

P4A – High Potent Capability

  • Typical input batch size: 0.5kg -> 1.5kg
  • Exposure Control Level: Band 5*

Equipment:

Reactors x3

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Tanks x3

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Gloveboxes x 2

Filter Dryers x 1

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Swords Campus Band System *

  • This Band System is used at the Swords Campus. APIs will be assigned a specific EG (Exposure Guideline) e.g Apixaban is 0.003 mg/m³) therefore band 4
  • Intermediates are not assigned an EG, so will instead be placed into a a band & generally controlled to midpoint of band
  • The band relates to potency, with band 5 Special Case being the most potent material
  • The more potent the material, the more containment required to control the exposure. The engineering in P4/P4A are capable of containing band 5/5 special care
Band CRange MG/M³
1 1.0
2 0.1<1.0
3 0.01<0.1
4 0.001<0.01
5 0.001<0.0001
5 special case <0.0001

Utilities

Chillers

Plants P4, P7, P4A:

  • Energy efficient, environmentally friendly bespoke chillers -30c degrees on duty/standby mode

Plants P3, P8:

  • Glycol System to -15c degrees on duty/standby mode
  • Glycol System +4c degrees on duty/standby mode
  • Syltherm System to -30 back up on duty/standby mode

Plant P9:

  • Syltherm System -30c degrees on duty/standby mode

Water Purification

Plant P4, P4A, P7:

  • High-quality purified water system x 2

Plant P4, P4A, P7:

  • High-quality purified water system
  • Hydrogenation Plant
  • High-quality purified water system

Water Cooling

  • 2 x Cooling water reservoirs cooled by 5 cell induced draft counter flow evaporative open cooling towers.

Water Waste

  • State of the art waste water treatment plant.

Steam Plant

  • Clayton Steam generation plant operating in duty assist mode with back-up steam generation system available.

Thermal Oxidiser

  • Fume Abatement System operating at 1,1000°C.

Nitrogen Oxidiser

  • Nitrogen generation units using Liquid Nitrogen x 2
  • Compressed nitrogen PSA plant x 1

Solvent Recovery Plant

  • 12 bulk fresh solvent underground bunded storage tanks
  • 10 over ground recovered solvent tanks

Air Compressors

  • 3 x compressors supplying compressed air operating in the duty assist standby mode
  • Separate breathing air compression system

Generators

  • Back-up generator for key functions

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