Material Science and Particle Engineering2021-03-12T10:59:33+00:00

Material Science and Particle Engineering

We are experts in particle engineering and solid state chemistry. Our group is comprised of a team of skilled scientists with several years experience in a GMP pharmaceutical site. We have a strong track record of delivering results, from process development and scale-up to optimisation of commercial products. We also provide full monitoring of crystallisation processes with on-scale PAT.

The team plays a vital role in supporting the following areas using specialised instrumentation and advanced analytical techniques:

  • Crystallisation process development and optimisation
  • Predictive modeling for scale up and technology transfer
  • Process safety studies
  • Solid state characterisation
  • Continuous process verification (process robustness) for manufacturing operations
  • Investigations and extraneous matter support

Material Science Analytical Techniques:

  • Differential Scanning Calorimetry (DSC)
  • X-ray Powder Diffraction (XRPD)
  • Scanning Electron Microscope (SEM)
  • Optical Microscope
  • Particle size distribution: Malvern Mastersizer and Morphologi G3
  • Surface area analysis
  • FT4 powder rheometry
  • Spectroscopy (FTIR-ATR and Raman)
  • Hot stage microscope
  • Dynamic Vapour Sorption (DVS)
  • Thermogravimetric Analysis (TGA)

Particle Engineering Capabilities:

  • Solubility and form design space mapping
  • Purity by design of crystallisation
  • Mixing analysis and scale-up
  • Particle size optimisation through design of crystallisation and micronisation
  • In-process form control
  • Filtration benchmarking
  • Particle attrition and drying studies
  • Multiple particle size analyser in-line PAT probes

Analytical Capabilities in R&D

AGILENT CARY 630 FTIR: Foreign matter analysis

ANTARIS II NIR: Polymorph/solvate identification

TA Q2500 DSC: Modulated DSC Polymorph/solvate identification

BRUKER D8 ADVANCE: Polymorph identification

NICOLET RAMAN: Chemical/Polymorph identification

AGILENT GC-R: Chemical identification & quantification

AGILENT ICP-R/OES: Chemical identification & quantification

AGILENT LC-R: Chemical identification & quantification

MALVERN MASTERSIZER 3000: Particle size & distribution

LEICA DM 3000: Imaging technique

JEOL NEOSCOPE 5000 SEM: Imaging technique

MALVERN MORPHOLOGI G3: Image analysis for particle size & shape

FREEMAN FT4 Powder rheometer: Bulk density, flow & compaction properties

MICROMETRICS TRISTAR II PLUS: B.E.T. Specific surface area, pore size distribution

DVS RESOULTION: Dual Vapour Gravimetric Analyser

TA Q550 TGA: Thermal Gravimetric Analyser

Hot Stage Microscope: Visualise Thermal Phase Transitions


Laboratory Capabilities: Experimental Diagnostics

Process Control
Crystallisation Development
Isolation Performance
Final PSD Control

Mettler Toledo RX10 reactor control setup

Programming of heating/ cooling/ dosing trends and trending of isotherms, process parameters, dosing rates

Lasentec FBRM

Data-rich real time nucleation, dissolution and crystallisation analytics

Pressurised leaf filter

Benchmarking filtration performance on lab scale, flux rates, cake compressibility, specific cake resistance measurements

Chemglass Process Filter Dryer

Attrition-on-drying studies, wet and dry compressed cake attrition, agitated deliquoring studies

IKA Wet Mill

Manual processing of slurries to achieve a desired particle size distribution

Contact Us Today

For Business Development & Marketing Enquires contact:
For Recruitment Enquiries contact:
For Media and General Enquiries contact:

contact us