Capabilities: Material Science and Particle Engineering
Capabilities:
Material Science and Particle Engineering
Material Science and Particle Engineering
We are experts in particle engineering and solid state chemistry. Our group is comprised of a team of skilled scientists with several years experience in a GMP pharmaceutical site. We have a strong track record of delivering results, from process development and scale-up to optimisation of commercial products. We also provide full monitoring of crystallisation processes with on-scale PAT.
The team plays a vital role in supporting the following areas using specialised instrumentation and advanced analytical techniques:
- Crystallisation process development and optimisation
- Predictive modeling for scale up and technology transfer
- Process safety studies
- Solid state characterisation
- Continuous process verification (process robustness) for manufacturing operations
- Investigations and extraneous matter support
Material Science Analytical Techniques:
- Differential Scanning Calorimetry (DSC)
- X-ray Powder Diffraction (XRPD)
- Scanning Electron Microscope (SEM)
- Optical Microscope
- Particle size distribution: Malvern Mastersizer and Morphologi G3
- Surface area analysis
- FT4 powder rheometry
- Spectroscopy (FTIR-ATR and Raman)
- Hot stage microscope
- Dynamic Vapour Sorption (DVS)
- Thermogravimetric Analysis (TGA)
Particle Engineering Capabilities:
- Solubility and form design space mapping
- Purity by design of crystallisation
- Mixing analysis and scale-up
- Particle size optimisation through design of crystallisation and micronisation
- In-process form control
- Filtration benchmarking
- Particle attrition and drying studies
- Multiple particle size analyser in-line PAT probes
Analytical Capabilities in R&D
AGILENT CARY 630 FTIR: Foreign matter analysis
ANTARIS II NIR: Polymorph/solvate identification
TA Q2500 DSC: Modulated DSC Polymorph/solvate identification
BRUKER D8 ADVANCE: Polymorph identification
NICOLET RAMAN: Chemical/Polymorph identification
AGILENT GC-R: Chemical identification & quantification
AGILENT ICP-R/OES: Chemical identification & quantification
AGILENT LC-R: Chemical identification & quantification
MALVERN MASTERSIZER 3000: Particle size & distribution
LEICA DM 3000: Imaging technique
JEOL NEOSCOPE 5000 SEM: Imaging technique
MALVERN MORPHOLOGI G3: Image analysis for particle size & shape
FREEMAN FT4 Powder rheometer: Bulk density, flow & compaction properties
MICROMETRICS TRISTAR II PLUS: B.E.T. Specific surface area, pore size distribution
DVS RESOULTION: Dual Vapour Gravimetric Analyser
TA Q550 TGA: Thermal Gravimetric Analyser
Hot Stage Microscope: Visualise Thermal Phase Transitions
AGILENT 708DS-DISSOLUTION WITH IN-LINE UV: Dissolution rate
Laboratory Capabilities: Experimental Diagnostics
Mettler Toledo RX10 reactor control setup
Programming of heating/ cooling/ dosing trends and trending of isotherms, process parameters, dosing rates
Lasentec FBRM
Data-rich real time nucleation, dissolution and crystallisation analytics
Pressurised leaf filter
Benchmarking filtration performance on lab scale, flux rates, cake compressibility, specific cake resistance measurements
Chemglass Process Filter Dryer
Attrition-on-drying studies, wet and dry compressed cake attrition, agitated deliquoring studies
IKA Wet Mill
Manual processing of slurries to achieve a desired particle size distribution
Contact Us Today
For Business Development & Marketing Enquires contact: info@skpharmteco.com
For Recruitment Enquiries contact: careersireland@skbiotek.ie
For Media and General Enquiries contact: info@skpharmteco.com