Continuous Processing2020-05-21T19:18:39+00:00

SK biotek Continuous Process Technology

A world leader in development of custom cGMP Chemical Manufacturing of APIs and Intermediate by Continuous Flow Process . With state-of-art manufacturing facilities, the capability to manufacture APIs and, Intermediates, plus the ability to scale-up from kilos to multi-ton for global leading pharmaceutical companies.

SK biotek is the leading supplier of late phase and commercial pharmaceutical materials using Continuous Flow Processing. Continuous Flow Processing has many advantages over traditional batch processes; it is not just greener, highly efficient, cost effective and regulatory supported; but also has the capability to conduct low temperature reactions, hazardous reactions (Azide/Hydrogen Peroxide etc.), catalytic reactions, and other extreme chemistries not possible by batch processing.

Continuous Process Manufacturing Offers

  • Improvement in the degree of purity achieved and/or higher process yield
  • Avoids cryogenic process steps
  • Simplifies process scale-up
  • Achieves a higher process stability
  • Enables safe operation of reactions otherwise not possible in batch mode
  • Improves levels of process control through Quality by Design (QbD) approaches, combining improved process economics versus batch operations

Our Expert Equipment and Capabilities

  • Continuous Process Development and Optimization
  • Organic / Analytical Chemists and Chemical Engineers / Organic Chemists
  • New Synthetic Route Design for Continuous Process
  • Process Validation / Method Validation
  • Integration of Batch and Continuous Process
  • Fixed Bed Catalyst Reaction and Micro-Reactor Technology

Continuous Flow Process in SKBT

Tubular & Fixed Bed Reactor

Cryogenic Reaction

  • Halogen-Metal Exchange
  • Alkynylation
  • Enolate Chemistry

Hazardous Reaction

  • H2O2 Oxidation
  • Azide Chemistry
    Curtius rearrangement, Tetrazole, Triazole synthesis

Catalysis (Homogeneous)

  • Enantioselective Hydrogenation
  • Enantioselective Reductive Amination

Catalysis (Heterogeneous)

  • Het. Catalyst Technology
    Design, screening and manufacturing
  • Hydrogenation
    Rosenmund reduction, Lactam reduction

Continuous Process Development Equipment in R&D

Key Equipment in R&D

  • Process development instrument
  • General and batch process development
  • RC1, DSC, Multi-max, Opti-Max, Easy-Max, FBRM, Autoclave, Jet-mill, Multi-reactors, Microscope, Easy-sampler
  • Continuous process development
  • Low temperature Continuous Tubular Reactors
Material Flow Rate No. of Units Max Pressure Min Temperature
Lab 316LSS 30ml/min 3 5 atm -60°C
Bench & Pilot 316LSS + H/C 250ml/min 2 5 atm -80°C
  • High Temperature Continuous Tubular Reactors
Material Flow Rate No. of Units Max Pressure Min Temperature
Lab 316LSS 20ml/min 3 70 atm 200°C
Pilot 316LSS + H/C 200ml/min 1 70 atm 230°C
  • Continuous Fixed Bed Reactors
Catalyst Volume No. of Units Max Pressure Max Temperature
Mini 5 ~ 20ml 9 100 atm 650°C
Bench S 100 ~ 300ml 1 250 atm 650°C
Bench L 300 ~ 500ml 1 250 atm 650°C
  • Continuous workup equipment: Continuous distillation(SPD), Continuous extractor, Continuous crystallization
  • Analytical instrument
  • NMR, ICP-R, LC-R, GC-R, HS-GC, UPLC, HPLC, CAD, GC, XRD

Scale-up of Continuous Catalytic Reaction

4-Stage Evaluation System: Lab Bench Pilot Commercial Plant

Lab

  • Continuous (High P)
  • Batch (Autoclave)

Bench

  • Continuous (High P)
  • Series reactor system

Pilot (250atm)

  • Reactor 20 L, max. 400°C

Commercial Plant (120atm)

  • Reactor 220 L, max. ~200°C

Commercial Plant (330atm)

  • Reactor 450 L, max. ~170°C

Scale-up of Continuous Tubular Reaction

Lab

  • Material: 316LSS
  • Flow rate: 30ml/min
  • Scale: ~ hundreds of grams

Pilot (Low temperature)

  • Material: 316LSS + H/C
  • Flow rate: 250ml/min
  • Scale: ~ tens of kilograms

Pilot (High temperature)

  • Material: 316LSS + H/C
  • Flow rate: 200ml/min
  • Scale: ~ tens of kilograms

Commercial (Low temperature)

  • Material: 316LSS/ Flow rate: 1L/min
  • Japanese PMDA (2013) & US FDA (2014) approved
  • Currently producing over 30MT/year
  • Production Capacity: 4 MT/month

Continuous Tubular Reaction System

Low Temperature Continuous Reaction System
(Daejeon)

  • Operation Range : -80°C ~ +20°C
  • Controlled and Monitored by PLC System
  • Lithiation with Butyl-Li, Hex-Li
  • 2 Set, 316LSS, + Hastelloy-C , In-line Mixer
  • Production Capacity: 4 MT/month

Continuous Oxidation Reaction System
(Daejeon)

  • Oxidation with 50% H2O2
  • 1 Set, Hastelloy-C, Tubular Reactor
  • Production Capacity: 3MT/month

Low Temperature Continuous Reaction System
(Sejong Plant)

  • Operation Range : -80°C ~ +20°C
  • Controlled and Monitored by PLC System
  • Lithiation with Butyl-Li, Hex-Li
  • 2 Set, 316LSS + Hastelloy-C, In-line Mixer
  • Production Capacity: 4 MT/month

Low Temperature Continuous
Reactor (Daejeon)

Continuous Oxidation Reactor
(Daejeon)

Low Temperature Continuous
Reactor (Sejong Plant)

Low Temperature Continuous
Reactor (Sejong Plant)

Continuous Workup Equipment

High Vacuum Distillation Equipment

  • Hybrid SPD(Daejeon)
    • Operating Condition : 50~250°C , < 0.1mbar Capacity : 15 kg/hr
    • 316LSS, 110L*2ea,

Hybrid SPD
(Daejeon)

Pilot Plant

Low Temperature Continuous Reaction System

  • Movable-type
  • – 80°C ~ +20°C

Packed Bed Column Reactor for Continuous Catalytic Reaction

  • 20 L * 1 EA
  • 200 bar, 400°C

Pilot Scale Low Temp.
Continuous Reaction System
(Movable-type)

Pilot scale Packed Bed
Column Reactor

Pilot Scale High Temp.
Continuous Reaction System

Contact Us Today

For Business Development & Marketing Enquires contact: skbiotekmarketing@sk.com
For Recruitment Enquiries contact: skbtcareers@sk.com
For Media and General Enquiries contact: communications@sk.com

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