Advanced Synthesis Platform
Our experience with complex chemical transformations on both small and large scale spans decades. Our laboratories are equipped to support the manufacture of pharmaceutical products across a wide range of processes covering carbon-carbon and carbon-heteratom bond formation, chiral chemistry, REDOX reactions and protecting group chemistry. We have extensive on-scale experience with highly telescoped processes.
We offer the following Process Development services:
- Lactamisation
- Mixed anhydride formation
- Nucleophilic aromatic substitution
- Amidation
- SN2 epoxide ring-opening
- Buchwald-Hartwig amination
- Classical resolution
- Sharpless asymmetric epxoidation
- Oxygen-sensitive coupling
- Heck and Vielsmeier coupling
- Esterification
- Hydrogenation
- Red-Al reduction
- Glycoside reduction
- Peroxide and hypochlorite oxidation
- Fleming oxidation
- Staudinger reduction
- Dehydration of amide to nitrile
- Allylation
- Halogenation
- Protecting group chemistry (acetalisation, orthoester formation, de-Bocylation)
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